Sexual Health — Updates Since 2020

Guideline & practice changes since 2020

  • Long-acting injectable PrEP (cabotegravir, Apretude) is now an option alongside daily oral tenofovir/emtricitabine and on-demand (2-1-1) dosing. See HIV Prevention — PrEP & PEP.
  • Gonorrhoea remains a dual-therapy, resistance-driven target: ceftriaxone 500 mg IMI plus azithromycin 1 g PO for uncomplicated genital/anorectal infection, with a higher azithromycin dose for pharyngeal infection and a higher ceftriaxone dose for gonococcal conjunctivitis; local resistance patterns and susceptibility results should still be checked. See Gonorrhoea.
  • The syphilis outbreak in Aboriginal and Torres Strait Islander communities that began in Queensland has continued to spread, and multiple outbreaks are now running concurrently across Australia — check current public health alerts for the affected regions rather than relying on a fixed list. See Syphilis.
  • The National HPV Vaccination Program uses 9-valent Gardasil 9, covering more genotypes than the original quadrivalent vaccine. See Anogenital Warts (HPV).
  • Mpox vaccination (JYNNEOS/MVA-BN) now covered: ATAGI eligibility, 2 × 0.5 mL SC 28 days apart, PEP within 14 days, best protection 2 weeks after dose 2 (~80%), side effects and contraindications (Immunisation Handbook Jan 2026; NSW Health Feb 2026). See Mpox (2026-09-17).

New pages added

  • Mpox (2026-09-01) — presentation and complications, specimen collection and testing indications, supportive management and when to involve infectious diseases/sexual health specialists, isolation criteria and transmission risk via semen.