Perianal Streptococcal Infection
Written 2nd March 2020 - Last Update 17th August 2026
Perianal Streptococcal Infection
Condition
An infectious condition of the skin around the anus in preschool and school-age children, caused by Group A beta-haemolytic streptococcus. Presents as a persistent, itchy, tender, erythematous perianal eruption extending from the anal verge. May be accompanied by fissures, bleeding, discharge, constipation, and pain with defecation. May also involve inflammation of the vulva and vagina in girls, or the end of the penis in boys.

Diagnosis
A perianal swab for bacterial culture confirms the diagnosis.
Management
Perianal infections treated with penicillin recur at a high rate; clinical trials show efficacy for oral cephalosporins.
- Cefalexin 1g twice daily for 5 days, or
- Clindamycin 450mg three times daily for 5 days, or
- Trimethoprim/sulfamethoxazole 160/800mg twice daily for 5 days.